1. Elevated High-Density Lipoprotein Cholesterol Is Associated with Hyponatremia in Hypertensive Patients 
Ariel Israel, MD, PhD, Ehud Grossman, MD 
The American Journal of Medicine 
Volume 130, Issue 11, Pages 1324.e e13 (November 2017)
DOI: /j.amjmed
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
Receiver operator characteristic curves (ROC) for gradient boosting models predicting the risk of future hyponatremia using baseline participant characteristics: the red curve describes the full model, the black curve describes a model that was trained without some variables from the lipid profile (high-density lipoprotein, total cholesterol, and triglycerides). The vertical lines give the false positive rate for the predetermined sensitivity of 50%. AUC = area under the curve.
The American Journal of Medicine  , 1324.e e13DOI: ( /j.amjmed )
Copyright © 2017 Elsevier Inc. Terms and Conditions

3. Figure 2
Density plots comparing high-density lipoprotein cholesterol (HDL-C) at baseline in Systolic Blood Pressure Intervention Trial (SPRINT) participants who developed hyponatremia (red) during the study and patients who did not develop hyponatremia (blue). Baseline HDL-C was significantly more elevated in participants who later developed hyponatremia, for both males and females (P <.0001 in both sexes; Wilcoxon test).
The American Journal of Medicine  , 1324.e e13DOI: ( /j.amjmed )
Copyright © 2017 Elsevier Inc. Terms and Conditions

4. Figure 3
Kaplan-Meier plots comparing the occurrence of hyponatremia events for patients in the highest high-density lipoprotein cholesterol (HDL-C) quintile, with the rest of the patients, both in the standard treatment arm (A) and the intensive treatment arm (B).
The American Journal of Medicine  , 1324.e e13DOI: ( /j.amjmed )
Copyright © 2017 Elsevier Inc. Terms and Conditions