1. Volume 117, Issue 1, Pages 167-172 (July 1999)
Assessment of biliary bicarbonate secretion in humans by positron emission tomography 
Jesús Prieto*, Nicolás García*, Josep M. Martí-Climent‡, Iván Peñuelas‡, José A. Richter‡, Juan F. Medina* 
Gastroenterology 
Volume 117, Issue 1, Pages (July 1999)
DOI: /S (99)
Copyright © 1999 American Gastroenterological Association Terms and Conditions

2. Fig. 1
NaH11CO3 PET in healthy subjects. The kinetics of label uptake (in NU) have been graphed for a representative parenchymal area and perihilar region both in the basal state (left) and after intravenous administration of secretin (right).
Gastroenterology  , DOI: ( /S (99) )
Copyright © 1999 American Gastroenterological Association Terms and Conditions

3. Fig. 2
NaH11CO3 PET imaging of the liver in a typical healthy subject. Transverse sections through the hilum, each with data from 3 consecutive time frames. (A) PET study performed under basal conditions, i.e., without secretin stimulation (lower threshold is set to 25%). (B) PET study performed after secretin administration (no background subtraction is applied). Arrow indicates the intense radioactivity uptake signal at the perihilar region after secretin stimulation. Data for each image have been normalized to the maximal pixel value (indicated at the top of the corresponding color spectrum).
Gastroenterology  , DOI: ( /S (99) )
Copyright © 1999 American Gastroenterological Association Terms and Conditions

4. Fig. 3
NaH11CO3 PET in patients with cirrhosis, extrahepatic biliary obstruction, and PBC. The kinetics of label uptake (in NU) have been graphed for a representative perihilar region in each patient both in the absence of secretin (left) and after secretin administration (right). Colored PET curves in the middle panels correspond to the same patient with extrahepatic biliary obstruction who was studied before (green) and after (red) surgical decompression of the obstruction. In the lower right panel, untreated patients with PBC (n = 3) are represented in red and UDCA-treated patients (n = 6) in black (heavy lines correspond to repeated studies in subjects who were also investigated before therapy).
Gastroenterology  , DOI: ( /S (99) )
Copyright © 1999 American Gastroenterological Association Terms and Conditions

5. Fig. 4
NaH11CO3 PET imaging in a patient with PBC after stimulation with secretin. Transverse sections through the hilum, each collecting data from three consecutive 20-second-frames. (A) PET study performed before UDCA treatment (lower threshold is set to 25%). (B) PET study performed after subject had undergone UDCA therapy for 8 months (lower threshold, 10%). Arrow indicates the intense radioactivity uptake signal at the perihilar region on secretin stimulation after UDCA therapy. Data for each image have been normalized to the maximal pixel value (indicated at the top of the corresponding color spectrum).
Gastroenterology  , DOI: ( /S (99) )
Copyright © 1999 American Gastroenterological Association Terms and Conditions