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Caging Targets for Destruction

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Presentation on theme: "Caging Targets for Destruction"— Presentation transcript:

1 Caging Targets for Destruction
Luisa M. Stamm, Danielle M. Heller, Marcia B. Goldberg  Cell Host & Microbe  Volume 8, Issue 5, Pages (November 2010) DOI: /j.chom Copyright © 2010 Elsevier Inc. Terms and Conditions

2 Figure 1 Model of the Tug-of-War between Intracytosolic Shigella and Host Cell Defenses Early after Cellular Infection, as Demonstrated by Mostowy et al. in the Current Issue of Cell Host & Microbe A subset of intracytosolic Shigella polymerizes actin tails and spreads into adjacent cells, while other intracytosolic Shigella are trapped in cages formed by cellular septin proteins. Septin cages play a critical role in targeting Shigella to the autophagocytic pathway. Myosin II contributes to the targeting of Shigella to the autophagosome, and its inhibition enables Shigella to escape from septin cages. Cell Host & Microbe 2010 8, DOI: ( /j.chom ) Copyright © 2010 Elsevier Inc. Terms and Conditions


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