1. Volume 121, Issue 5, Pages 1226-1233 (November 2001)
Emergence of a distinct pattern of viral mutations in chimpanzees infected with a homogeneous inoculum of hepatitis C virus 
Michael Thomson, Michelina Nascimbeni, Sophia Gonzales, Krishna K. Murthy, Barbara Rehermann, T.Jake Liang 
Gastroenterology 
Volume 121, Issue 5, Pages (November 2001)
DOI: /gast
Copyright © 2001 American Gastroenterological Association Terms and Conditions

2. Fig. 1
Inoculation and infection course of chimpanzee X0142. This animal was transfected intrahepatically with 0.5 mg RNA transcribed from the HCV 1b clone pHCV-CG1b. (A) Serum ALT values (light gray area: normal limits are U/L), and HCV RNA levels (bars), as determined by Taqman RT-PCR. Above the chart are indicated histology results of the biopsies denoted by arrows, qualitative HCV RNA data, and EIA 2.0 data. (B) T-cell proliferative responses for several HCV antigens. A stimulation index (SI) of greater than 4.0 was considered positive. As positive controls, T cells were stimulated nonspecifically with phytohemagglutinin (SI in the range 12-80).
Gastroenterology  , DOI: ( /gast )
Copyright © 2001 American Gastroenterological Association Terms and Conditions

3. Fig. 2
Mutation analysis of serum HCV RNA from chimpanzees X0142 and X0234. A diagram of the HCV genome is shown at the top, with numbers referring to the nt at the 5' position of each gene. The nt sequence of PCR-amplified HCV cDNA was determined for HCV nts 50 to 9400 at various time points after infection, and compared with that of pHCV-CG1b. UTR, untranslated region.
Gastroenterology  , DOI: ( /gast )
Copyright © 2001 American Gastroenterological Association Terms and Conditions

4. Fig. 3
Inoculation and infection course of chimpanzee X0234. This animal was inoculated on 4 occasions with increasing concentrations of week 2 serum from X0142 (Figure 1). X0234 was first inoculated with a 105 dilution, then 104, 103, and 102 dilutions, the last one causing an infection and shown as week 0.
Gastroenterology  , DOI: ( /gast )
Copyright © 2001 American Gastroenterological Association Terms and Conditions