1. Case study 14
Hadeel , Huda , Abeer

2. Man 35 years old come to emergency room and
has symptom :
Pallor , fever, excessive sweating, weight lost
frequent bleeding , frequent infection
The doctor request some test :

3. Normal range
Result
Parameter M
3.5M
RBC
70000
WBC 9 HB
145000
PLT

4. Blood smear

5. Bone marrow
Myeloblastic with maturation
Blast cell >20%

6. Cytochemistry :
MPo + , suddan black + , PAS –
Cytogenetic :
Translocation between chromosome 8 and 21
Cell surface marker :
CD13 , CD 33 , CD 15

7. AML –M2
50% > myeloblast and promyelocyte and common single auer rod
Can be differentiation between AML –M2 and CML by number of blast cell in bone marrow
M2 >20% blast
CML <20%