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Synaptic [Ca2+] Neuron Volume 22, Issue 3, Pages 427-430 (March 1999)
Karel Svoboda, Zachary F Mainen Neuron Volume 22, Issue 3, Pages (March 1999) DOI: /S (00)
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Figure 1 Synaptic Ca2+ in Spines of Cerebellar Purkinje Cells
(Top) Schematic representation showing the pathways of Ca2+ entry. Blue arrows indicate flow of Ca2+, white arrows indicate flow of current. mGlu-R, metabotropic glutamate receptor; VSCC, voltage-sensitive calcium channel; CATP, Ca2+-ATPase; ER, endoplasmic reticulum; RYR, ryanodine receptor; IP3R, IP3 receptor; CICR, Ca2+-induced Ca2+ release; SERCA, sarco\\endoplasmic reticulum Ca2+-ATPase. (Bottom) Schematic time course of [Ca2+] transients (ΔF/F is proportional to [Ca2+]) evoked by synaptic stimuli (STIM) in the presence of various drugs (Finch and Augustine 1998; Takechi et al. 1998). Neuron , DOI: ( /S (00) )
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Figure 2 Synaptic Ca2+ in Spines of CA1 Hippocampal Pyramidal Neurons
(Top) Schematic representation showing the pathways of Ca2+ entry. Note that only a subpopulation of spines contain ER. For abbreviations, see the Figure 1 legend. Some IP3 receptors may also exist in CA1 spines (Sharp et al. 1993). (Bottom) Schematic time course of [Ca2+] transients (ΔF/F) evoked by synaptic stimuli (STIM) in the presence and absence of blockers of CICR (Emptage et al. 1999). Neuron , DOI: ( /S (00) )
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