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Volume 86, Issue 2, Pages (August 2014)

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1 Volume 86, Issue 2, Pages 286-293 (August 2014)
Impaired vitamin K recycling in uremia is rescued by vitamin K supplementation  Nadine Kaesler, Elke Magdeleyns, Marjolein Herfs, Thomas Schettgen, Vincent Brandenburg, Danilo Fliser, Cees Vermeer, Jürgen Floege, Georg Schlieper, Thilo Krüger  Kidney International  Volume 86, Issue 2, Pages (August 2014) DOI: /ki Copyright © 2014 International Society of Nephrology Terms and Conditions

2 Figure 1 Overview of the different treatment groups. Seven weeks of treatment contained a 2-week interphase without adenine supplementation. *Protein content was lowered to 2.5% in the 7-week groups (see Supplemetary Table S2 online). All diets contained 5mg/kg vitamin (Vit) K1 (except diet in group i). Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

3 Figure 2 Undercarboxylated matrix Gla protein (ucMGP) measured in serum after 4 weeks of treatment. *P<0.05. Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

4 Figure 3 Hepatic vitamin K content. (a) Vitamin K1 measured in liver tissue after 7 weeks of diet; (b) MK4 measured in liver tissue after 7 weeks of diet. **P<0.01. Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

5 Figure 4 Quantification of undercarboxylated matrix Gla protein (ucMGP) staining in aortas after 7 weeks of treatment. *P<0.05. Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

6 Figure 5 The γ-glutamyl carboxylase (GGCX) activity. In kidneys after 4 (a) and 7 (b) weeks and in liver after 4 (c) and 7 (d) weeks (mean±s.d.). *P<0.05 and **P<0.01. Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

7 Figure 6 The γ-glutamyl carboxylase (GGCX) activity in aortas after 7 weeks (mean±s.d.) of treatment. *P<0.05. Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

8 Figure 7 The DT-diaphorase activity. In kidneys after 4 (a) and 7 (b) weeks and in liver after 4 (c) and 7 (d) weeks (mean±s.d.). *P<0.05. Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions


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