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Carbapenemase-producing Klebsiella pneumoniae: (when) might we still consider treating with carbapenems?  G.L. Daikos, A. Markogiannakis  Clinical Microbiology.

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Presentation on theme: "Carbapenemase-producing Klebsiella pneumoniae: (when) might we still consider treating with carbapenems?  G.L. Daikos, A. Markogiannakis  Clinical Microbiology."— Presentation transcript:

1 Carbapenemase-producing Klebsiella pneumoniae: (when) might we still consider treating with carbapenems?  G.L. Daikos, A. Markogiannakis  Clinical Microbiology and Infection  Volume 17, Issue 8, Pages (August 2011) DOI: /j x Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG. 1 Simulated concentration–time profiles of three different dosing regimens of meropenem. TI, traditional 30-min infusion; PI, prolonged 3-h infusion. Adapted from [35,45,47]. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

3 FIG. 2 Simulated target attainment probabilities for 50% time above the MIC (50% T > MIC) of three different regiments of meropenem. TI, traditional 30-min infusion; PI, prolonged 3-h infusion. Adapted from [36]. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions


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