1. International Journal of Cardiology
Time-to-isolation guided titration of freeze duration in 3rd generation short-tip cryoballoon pulmonary vein isolation – Comparable clinical outcome and shorter procedure duration 
Alexander Pott, Christoph Kraft, Tilman Stephan, Kerstin Petscher, Wolfgang Rottbauer, Tillman Dahme 
International Journal of Cardiology 
Volume 255, Pages (March 2018)
DOI: /j.ijcard
Copyright © 2017 The Authors Terms and Conditions

2. Fig. 1
Flowchart depicting cryoenergy dosing depending on TTI (TTI group) or with a fixed ablation protocol (fixed group). Freeze cycles in the TTI group are varied depending on TTI. Occurrence of TTI in the different categories is indicated. AF - atrial fibrillation; PV - pulmonary vein; PVI – pulmonary vein isolation; TTI - time-to-isolation.
International Journal of Cardiology  , 80-84DOI: ( /j.ijcard )
Copyright © 2017 The Authors Terms and Conditions

3. Fig. 2
Kaplan-Meier curves indicating freedom from atrial arrhythmia recurrence during follow-up after cryoballoon pulmonary vein isolation with a fixed ablation protocol (fixed group) or a time-to-isolation-guided ablation protocol (TTI group). (A) Freedom from atrial arrhythmia recurrence off class I or class III antiarrhythmic drugs after a three-months blanking period. (B) Freedom from atrial fibrillation recurrence off class I or class III antiarrhythmic drugs after a three-months blanking period.
International Journal of Cardiology  , 80-84DOI: ( /j.ijcard )
Copyright © 2017 The Authors Terms and Conditions

4. Supplementary Fig. 3
Kaplan-Meier curves indicating freedom from atrial arrhythmia recurrence independent of class I/III antiarrhythmic drug therapy during follow-up after cryoballoon pulmonary vein isolation with a fixed ablation protocol (fixed group) or a time-to-isolation-guided ablation protocol (TTI group). (A) Freedom from atrial arrhythmia recurrence after a three-months blanking period. (B) Freedom from atrial fibrillation recurrence after a three-months blanking period.
International Journal of Cardiology  , 80-84DOI: ( /j.ijcard )
Copyright © 2017 The Authors Terms and Conditions