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Nitric oxide synthase expression by pulmonary arteries: A predictive marker of Fontan procedure outcome?  Marilyne Lévy, MD, PhD, Claire Danel, MD, Anne-Marie.

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Presentation on theme: "Nitric oxide synthase expression by pulmonary arteries: A predictive marker of Fontan procedure outcome?  Marilyne Lévy, MD, PhD, Claire Danel, MD, Anne-Marie."— Presentation transcript:

1 Nitric oxide synthase expression by pulmonary arteries: A predictive marker of Fontan procedure outcome?  Marilyne Lévy, MD, PhD, Claire Danel, MD, Anne-Marie Laval, Francine Leca, MD, Pascal R. Vouhé, MD, Dominique Israël-Biet, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 125, Issue 5, Pages (May 2003) DOI: /mtc Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

2 Fig. 1 Light microscopy patterns of lung biopsies performed during Fontan procedures. (Original magnification for all panels 400×.) A, Normal nonmuscularized alveolar duct artery (arrowheads). B, Extension of muscle into the distal alveolar duct artery. Note the presence of muscle between the 2 laminae (arrowheads). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

3 Fig. 2 Relationship between the percentage wall thickness of the distal pulmonary arteries (external diameter <50 μm, μm, or μm) and outcome of the Fontan procedure. NS, Not significant. *P < .01, + P < .05. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

4 Fig. 3 Immunohistochemical studies showing eNOS expression in the pulmonary arteries: A, healthy control patients; B, group 1 patients (successful Fontan procedures); C, group 2 patients (failed Fontan procedures). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

5 Fig. 4 NOS immunostaining score in proximal (prox) and distal (dist) intra-acinar pulmonary arteries and capillaries (cap) in group 1 patients (successful Fontan procedures) and group 2 patients (failed Fontan procedures) versus that in normal control subjects. NOS expression is stronger in group 2 patients than in group 1 patients and normal control subjects. *P < .01. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

6 Fig. 5 Correlation between histomorphometric and immunohistochemical data. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

7 Fig. 6 ET-1 immunostaining score in proximal and distal intra-acinar pulmonary arteries and capillaries in group 1 patients (successful Fontan procedures) and group 2 patients (failed Fontan procedures) versus that in normal control subjects. *P < .01. Prox, Proximal intra-acinar pulmonary arteries; dist, distal intra-acinar pulmonary arteries; cap, capillaries. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

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