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Cold ischemia–induced damage to vascular endothelium results in permeability alterations in transplanted lungs  M.A. Hidalgo, MDa b, K.A. Shah, MRCPatha,

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Presentation on theme: "Cold ischemia–induced damage to vascular endothelium results in permeability alterations in transplanted lungs  M.A. Hidalgo, MDa b, K.A. Shah, MRCPatha,"— Presentation transcript:

1 Cold ischemia–induced damage to vascular endothelium results in permeability alterations in transplanted lungs  M.A. Hidalgo, MDa b, K.A. Shah, MRCPatha, B.J. Fuller, PhDb, C.J. Green, PhD, DSc(Med), FRCVS, FRCPath, FRCS(Hon), Acadn Ukr, AcadScia  The Journal of Thoracic and Cardiovascular Surgery  Volume 112, Issue 4, Pages (October 1996) DOI: /S (96) Copyright © 1996 Mosby, Inc. Terms and Conditions

2 Fig. 1 A, Control: Normal rat lung tissue. B, Alveolar edema and congestion after 48 hours of storage and 5 minutes of revascularization. (Original magnifications ×63.) The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

3 Fig. 1 A, Control: Normal rat lung tissue. B, Alveolar edema and congestion after 48 hours of storage and 5 minutes of revascularization. (Original magnifications ×63.) The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

4 Fig. 2 A, Perivascular edema after 48 hours of storage in a nonreperfused specimen. B, Alveolar hemorrhage after 72 hours of storage and 24 hours of revascularization. (Original magnifications: A, ×40; B, ×63.) The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

5 Fig. 2 A, Perivascular edema after 48 hours of storage in a nonreperfused specimen. B, Alveolar hemorrhage after 72 hours of storage and 24 hours of revascularization. (Original magnifications: A, ×40; B, ×63.) The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

6 Fig. 3 A, Bronchial epithelial surface blebbing after 48 hours of storage. B, Totally restored bronchial epithelium after 24 hours of revascularization, which followed 48 hours of storage. (Original magnifications ×400.) The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

7 Fig. 3 A, Bronchial epithelial surface blebbing after 48 hours of storage. B, Totally restored bronchial epithelium after 24 hours of revascularization, which followed 48 hours of storage. (Original magnifications ×400.) The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

8 Fig. 4 Electron micrographs of normal rat lung endothelium. The whole of the surface was covered with regularly shaped ECs in close contact with each other. (Original magnifications: A, ×1600; B, ×8000.) The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

9 Fig. 4 Electron micrographs of normal rat lung endothelium. The whole of the surface was covered with regularly shaped ECs in close contact with each other. (Original magnifications: A, ×1600; B, ×8000.) The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

10 Fig. 5 Electron micrographs of rat pulmonary arterial endothelium. A, Storage for 48 hours; B, storage for 72 hours and revascularization for 5 minutes. A small intercellular gap can be seen between two ECs (A), and a semidetached cell (B) exposes basal matrix. (Original magnifications ×8000.) The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

11 Fig. 5 Electron micrographs of rat pulmonary arterial endothelium. A, Storage for 48 hours; B, storage for 72 hours and revascularization for 5 minutes. A small intercellular gap can be seen between two ECs (A), and a semidetached cell (B) exposes basal matrix. (Original magnifications ×8000.) The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

12 Fig. 6 Electron micrographs of rat pulmonary arterial endothelium stored for 48 hours, followed by 5 minutes (A) or 24 hours (B) of revascularization. An increased number of surface microvilli and membrane blebs can be identified on EC surfaces at high magnification (A, original magnification ×8000). Discontinuities and loose intercellular connections can be appreciated at lower magnification (B, original magnification ×1600). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

13 Fig. 6 Electron micrographs of rat pulmonary arterial endothelium stored for 48 hours, followed by 5 minutes (A) or 24 hours (B) of revascularization. An increased number of surface microvilli and membrane blebs can be identified on EC surfaces at high magnification (A, original magnification ×8000). Discontinuities and loose intercellular connections can be appreciated at lower magnification (B, original magnification ×1600). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

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