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Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal.

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Presentation on theme: "Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal."— Presentation transcript:

1 Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer Risk  Chen Suo, PhD, Yajun Yang, PhD, Ziyu Yuan, MSc, Tiejun Zhang, PhD, Xiaorong Yang, PhD, Tao Qing, PhD, Pei Gao, MSc, Leming Shi, PhD, Min Fan, MSc, Hongwei Cheng, MD, Ming Lu, PhD, Li Jin, PhD, Xingdong Chen, PhD, Weimin Ye, PhD  Journal of Thoracic Oncology  Volume 14, Issue 4, Pages (April 2019) DOI: /j.jtho Copyright © 2019 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Association between ethanol oxidization rate (x axis) and acetaldehyde-metabolizing rate (y axis) and risk of esophageal squamous cell carcinoma in alcohol drinkers and non-alcohol drinkers, respectively. Boldface numbers in the blue and white rectangle regions represent ORs in the subgroups that are defined by rs671 and rs genotypes, where fast ethanol oxidization rate refers to rs (AG/GG), slow ethanol oxidization rate refers to rs (AA), fast acetaldehyde oxidization rate refers to rs671 (GG), and slow acetaldehyde oxidization rate refers to rs671 (AG). Non-alcohol drinkers who have a slow ethanol oxidization rate and fast acetaldehyde oxidization rate have the lowest risk and thus are used as the reference group. A, alanine; G, guanine. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2019 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Association between esophageal squamous cell carcinoma and alcohol consumption under certain metabolic capacity of alcohol. (A) Analysis stratified by genotypes of rs671 and rs The subgroups are labeled and defined as follows: ethanol-fast, fast ethanol oxidization rate for rs genotype AG/GG; ethanol-slow, slow ethanol oxidization rate for rs genotype AA; ethanal-fast, fast ethanal-metabolizing rate for rs671 genotype GG; and ethanal-slow, slow ethanal-metabolizing rate for rs671 genotype AG. (B) Stratified analysis by genotypes of rs671 and ethanol-metabolizing enzyme abundance level (E-MEAL) score. The subgroups are labeled and defined as follows: ethanol-fast, fast ethanol oxidization rate for E-MEAL less than 1; ethanol-slow, slow ethanol oxidization rate for E-MEAL score of 1 or higher; ethanol-fast, fast ethanal-metabolizing rate for rs671 genotype GG; and ethanal-slow, slow ethanal-metabolizing rate for rs671 genotype AG. A, alanine; G, guanine. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2019 International Association for the Study of Lung Cancer Terms and Conditions

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