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Angiotensin-converting Enzyme Inhibitors and Outcomes in Heart Failure and Preserved Ejection Fraction  Marjan Mujib, MD, MPH, Kanan Patel, MBBS, MPH,

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Presentation on theme: "Angiotensin-converting Enzyme Inhibitors and Outcomes in Heart Failure and Preserved Ejection Fraction  Marjan Mujib, MD, MPH, Kanan Patel, MBBS, MPH,"— Presentation transcript:

1 Angiotensin-converting Enzyme Inhibitors and Outcomes in Heart Failure and Preserved Ejection Fraction  Marjan Mujib, MD, MPH, Kanan Patel, MBBS, MPH, Gregg C. Fonarow, MD, Dalane W. Kitzman, MD, Yan Zhang, MS, MSPH, Inmaculada B. Aban, PhD, O. James Ekundayo, MD, DrPH, Thomas E. Love, PhD, Meredith L. Kilgore, PhD, Richard M. Allman, MD, Mihai Gheorghiade, MD, Ali Ahmed, MD, MPH  The American Journal of Medicine  Volume 126, Issue 5, Pages (May 2013) DOI: /j.amjmed Copyright © Terms and Conditions

2 Figure 1 Flow chart displaying assembly of inception cohort of matched patients with heart failure and preserved ejection fraction. ACE = angiotensin-converting enzyme; OPTIMIZE-HF = Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © Terms and Conditions

3 Figure 2 Love plot displaying absolute standardized differences comparing 114* baseline characteristics between older patients with heart failure and preserved ejection fraction, receiving a new discharge prescription of ACE inhibitors, before and after propensity score matching. A = admission; D = discharge; H = in-hospital; Hx = medical history; PF = precipitating factor. *Four regions entered as single categorical variable in the model. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © Terms and Conditions

4 Figure 3 Kaplan-Meier plot for primary composite end point of all-cause mortality or heart failure hospitalization in a propensity-matched inception cohort of older patients with heart failure and preserved ejection fraction receiving and not receiving a new discharge prescription for ACE inhibitors. ACE = angiotensin-converting enzyme; CI = confidence interval; HR = hazard ratio. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © Terms and Conditions

5 Figure 4 Association of a new discharge prescription of ACE inhibitors with primary composite end point of all-cause mortality or heart failure hospitalization in subgroups of propensity-matched inception cohort of older patients with heart failure and preserved ejection fraction. ACE = angiotensin-converting enzyme; CI = confidence interval; GFR = glomerular filtration rate. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © Terms and Conditions


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