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Validation of the IASLC/ATS/ERS Lung Adenocarcinoma Classification for Prognosis and Association with EGFR and KRAS Gene Mutations: Analysis of 440 Japanese.

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Presentation on theme: "Validation of the IASLC/ATS/ERS Lung Adenocarcinoma Classification for Prognosis and Association with EGFR and KRAS Gene Mutations: Analysis of 440 Japanese."— Presentation transcript:

1 Validation of the IASLC/ATS/ERS Lung Adenocarcinoma Classification for Prognosis and Association with EGFR and KRAS Gene Mutations: Analysis of 440 Japanese Patients  Akihiko Yoshizawa, MD, PhD, Shinji Sumiyoshi, MD, PhD, Makoto Sonobe, MD, PhD, Masashi Kobayashi, MD, Masakazu Fujimoto, MD, Fumi Kawakami, MD, Tatsuaki Tsuruyama, MD, PhD, William D. Travis, Hiroshi Date, MD, PhD, Hironori Haga, MD, PhD  Journal of Thoracic Oncology  Volume 8, Issue 1, Pages (January 2013) DOI: /JTO.0b013e aa8 Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Representative histologic pattern of lung adenocarcinoma (hematoxylin and eosin stains). A, Nonmucinous lepidic pattern; this area shows the lepidic growth pattern, composed of nonmucinous pneumocyte-like cells. B, Papillary pattern; this area shows the papillary configuration of the tumor gland. C, Micropapillary pattern; this area shows glandular cells growing in small papillary tufts lacking fibrovascular cores within retracted connective tissue spaceii. D, Acinar pattern; this area shows a glandular structure, composed of round- to oval-shaped glands with desmoplastic reaction. E, Solid pattern; this area shows solid sheets of tumor cells. F, Mucinous lepidic pattern; this area shows the lepidic growth pattern, composed of goblet-cell like cells with mucin. Journal of Thoracic Oncology 2013 8, 52-61DOI: ( /JTO.0b013e aa8) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 This scheme shows how the invasive area in lung adenocarcinoma is measured. The central area of the tumor shows, basically, a papillary pattern; the lepidic pattern and acinar pattern are seen in the peripheral area of this tumor. The invasive area was measured in a straight line across the largest diameter. Journal of Thoracic Oncology 2013 8, 52-61DOI: ( /JTO.0b013e aa8) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Correlations between frequencies of EGFR or KRAS mutations and the histologic subtype of the adenocarcinomas, based on the IASLC/ATS/ERS classification. A, y axis indicates the frequency of EGFR-mutated cases and the x axis indicates frequency of lung adenocarcinoma subtypes, based on the new IASLC/ATS/ERS classification; (B), y axis indicates the frequency of KRAS-mutated cases and the x axis indicates the frequency of lung adenocarcinoma subtypes, based on the IASLC/ATS/ERS classification. AIS, adenocarcinoma in situ, MIA, minimally invasive adenocarcinoma, Lepidic, lepidic predominant adenocarcinoma, Aci, acinar predominant adenocarcinoma, Pap, papillary predominant adenocarcinoma, Solid, solid predominant adenocarcinoma, MP, micropapillary predominant adenocarcinoma, IMA, invasive mucinous adenocarcinoma; IASLC, International Association for the Study of Lung Cancer; ATS, American Thoracic Society; ERS, European Respiratory Society. Journal of Thoracic Oncology 2013 8, 52-61DOI: ( /JTO.0b013e aa8) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 A, Disease-free survival curves and (B) overall survival curves, for the groups, separated by the IASLC/ATS/ERS classification of lung adenocarcinomas. AIS, adenocarcinoma in situ; MIA, minimally invasive adenocarcinoma; Lepidic, lepidic predominant adenocarcinoma; Aci, acinar predominant adenocarcinoma; Pap, papillary predominant adenocarcinoma; Solid, solid predominant adenocarcinoma; MP, micropapillary predominant adenocarcinoma; IMA, invasive mucinous adenocarcinoma; IASLC, International Association for the Study of Lung Cancer; ATS, American Thoracic Society; ERS, European Respiratory Society. Journal of Thoracic Oncology 2013 8, 52-61DOI: ( /JTO.0b013e aa8) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

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