1. Pharmacological blockade of the WNT-beta-catenin signaling: a possible first-in-kind DMOAD 
F. Dell'Accio 
Osteoarthritis and Cartilage 
Volume 26, Issue 1, Pages 4-6 (January 2018)
DOI: /j.joca
Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

2. Fig. 1
Inflammatory and mechanical stimuli activate canonical WNT signaling in cartilage. Controlled and transient activation ensures that homeostatic events take place and supports stem cell renewal. Excessive activation leads to osteoarthritis.
Osteoarthritis and Cartilage  , 4-6DOI: ( /j.joca )
Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions