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Changes in chondrocyte primary cilia structure and function are associated with altered mechanoregulation in Alkaptonuria  S.D. Thorpe, S. Gambassi, R.

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Presentation on theme: "Changes in chondrocyte primary cilia structure and function are associated with altered mechanoregulation in Alkaptonuria  S.D. Thorpe, S. Gambassi, R."— Presentation transcript:

1 Changes in chondrocyte primary cilia structure and function are associated with altered mechanoregulation in Alkaptonuria  S.D. Thorpe, S. Gambassi, R. Patel, A. Santucci, M.M. Knight  Osteoarthritis and Cartilage  Volume 24, Pages S174-S175 (April 2016) DOI: /j.joca Copyright © Terms and Conditions

2 Fig. 1. A. Representative primary cilia staining. B
Fig. 1. A. Representative primary cilia staining. B. Violin plot of cilia length. Black lines indicate median and interquartile range. ***: p < C. Representative super resolution structured illumination microscopy of ARL13b on cilia membrane. Line indicates profile position and arrow indicates distal tip of cilium. Osteoarthritis and Cartilage  , S174-S175DOI: ( /j.joca ) Copyright © Terms and Conditions

3 Fig. 2. Aggrecan and collagen 2 gene expression relative to 18sRNA
Fig. 2. Aggrecan and collagen 2 gene expression relative to 18sRNA. **: p < 0.01. Osteoarthritis and Cartilage  , S174-S175DOI: ( /j.joca ) Copyright © Terms and Conditions

4 Fig. 3. A. Representative primary cilia immunofluorescent staining with LiCl treatment. B. Violin plot of cilia length. ***: p < 0.001; a: p < vs. Healthy; b: p < vs. AKU. Osteoarthritis and Cartilage  , S174-S175DOI: ( /j.joca ) Copyright © Terms and Conditions


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