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Mark K. Hirko, MD, Joseph R. McShannic, MD, Steven P

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Presentation on theme: "Mark K. Hirko, MD, Joseph R. McShannic, MD, Steven P"— Presentation transcript:

1 Pharmacologic modulation of intimal hyperplasia in canine vein interposition grafts 
Mark K. Hirko, MD, Joseph R. McShannic, MD, Steven P. Schmidt, PhD, William V. Sharp, MD, M.Michelle Evancho, MS, Rick L. Sims, BS, James D. Siebert, MD  Journal of Vascular Surgery  Volume 17, Issue 5, Pages (May 1993) DOI: / (93)90037-M Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 1 Sample calculations of Gilman parameters. Three quantitative descriptions of intimal hyperplasia are presented. Intimal thickening is measured as area between dashed line and solid line (internal elastic lamina—original boundary of vessel lumen). A. Large venous interposition graft (Left, Graft 1): initial area = mm2, final perimeter = mm. B. Small venous interposition graft (Right, Graft 2): initial area = mm2, initial perimeter = mm, final area = 2.57 mm2, final perimeter = 6.95 mm. Journal of Vascular Surgery  , DOI: ( / (93)90037-M) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 2 Comparisons of mean Gilman parameters for carotid and femoral implantation sites at 6 weeks after operation for each drug treatment group. Journal of Vascular Surgery  , DOI: ( / (93)90037-M) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

4 Fig. 3 Mean Gilman parameters for midgraft and distal anastomotic graft segments from dogs in each drug treatment group at 1 week after operation. Journal of Vascular Surgery  , DOI: ( / (93)90037-M) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

5 Fig. 4 Mean Gilman parameters for midgraft and distal anastomotic graft segments from dogs in each drug treatment group at 3 weeks after operation. Journal of Vascular Surgery  , DOI: ( / (93)90037-M) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

6 Fig. 5 Mean Gilman parameters for midgraft and distal anastomotic graft segments from dogs in each drug treatment group at 6 weeks after operation. Journal of Vascular Surgery  , DOI: ( / (93)90037-M) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

7 Fig. 6 A, Cross section of autogenous vein midgraft segment obtained from control, nonmedicated dog at 6 weeks after operation. (Masson's trichrome stain; original magnification × 10.) B, Cross section of an autogenous vein midgraft segment obtained from a cyclosporine-medicated dog at 6 weeks after operation. (Masson's trichrome stain; original magnification × 10.) Journal of Vascular Surgery  , DOI: ( / (93)90037-M) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

8 Fig. 7 A, Photomicrograph of the intima from a midgraft segment of an autogenous vein graft from a control, nonmedicated dog at 6 weeks after operation. (Hematoxylin-eosin; original magnification × 400.) B, Photomicrograph of intima from midgraft segment of autogenous vein graft from cyclosporine-treated dog at 6 weeks after operation. (Hematoxylin-eosin; original magnification × 400.) Journal of Vascular Surgery  , DOI: ( / (93)90037-M) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

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