1. Tubular injury as a cardinal pathologic feature in human heme oxygenase-1 deficiency 
Kazuhide Ohta, MD, Akihiro Yachie, MD, Kayoko Fujimoto, MD, Hisashi Kaneda, MD, Taizo Wada, MD, Tomoko Toma, MD, Akiko Seno, MD, Yoshihito Kasahara, MD, Hitoshi Yokoyama, MD, Hidetoshi Seki, MD, Shoichi Koizumi, MD 
American Journal of Kidney Diseases 
Volume 35, Issue 5, Pages (May 2000)
DOI: /S (00)
Copyright © 2000 National Kidney Foundation, Inc Terms and Conditions

2. Fig 1
Light microscopic findings in the initial renal biopsy. (A) Hematoxylin-eosin, (B) periodic acid–Schiff, (C) periodic acid–methenamine silver, and (D) azan staining.
American Journal of Kidney Diseases  , DOI: ( /S (00) )
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3. Fig 2
Electron microscopic examination of the initial renal biopsy. *An unidentifiable material was deposited between the detached endothelium. Abbreviations: Pod, podocyte; Cap, capillary lumen (original magnification [A] ×6,000 and [B] ×40,000).
American Journal of Kidney Diseases  , DOI: ( /S (00) )
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4. Fig 3
Kidney specimens at autopsy were stained with (A) periodic acid–Schiff and (B) azan.
American Journal of Kidney Diseases  , DOI: ( /S (00) )
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5. Fig 4
Immunoblotting and immunohistochemistry of haptoglobin. The samples are concentrated urine of the patients with HO-1 deficiency (Pt) and minimal change nephrotic syndrome (MCNS) in the acute phase. The urine sample from the HO-1–deficient patient showed a significant amount of type 2-2 haptoglobin. (A) All these bands show type 2-2 haptoglobin. (B) Haptoglobin (arrow) was observed within the proximal tubular epithelium of the HO-1–deficient patient, but not (C) the patient with MCNS. Abbreviation: gl, glomerulus.
American Journal of Kidney Diseases  , DOI: ( /S (00) )
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6. Fig 5
Immunohistochemical demonstration of HO-1. HO-1 was not detected in (A) the renal specimen of the deficient patient but was detectable in various renal diseases, namely, (B) acute tubular necrosis, (C) IgA nephropathy, and (D) minimal change nephrotic syndrome in the remission stage.
American Journal of Kidney Diseases  , DOI: ( /S (00) )
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