1. Recent Scientific Findings from The Clinical Trials Network
Betty Tai, Ph.D.
Steven Sparenborg, Ph.D. (CTN-0009)
Petra Jacobs, M.D. (CTN-0013)
Raúl Mandler, M.D. (CTN-0019)
Paul Wakim, Ph.D. (Secondary Analysis)

2. Smoking Cessation Treatment in Community-based Substance Abuse Rehabilitation Programs
Malcolm S. Reid, Bryan Fallon, Susan Sonne,
Frank Flammino, Edward V. Nuñes, Huiping Jiang,
Eva Kourniotis, Jennifer Lima, Ron Brady, Cynthia Burgess, Cynthia Arfken, Eric Pihlgren, Louis Giordano,
Aron Starosta, James Robinson, John Rotrosen
Journal of Substance Abuse Treatment 2008
35(1): 68–77
CTN-0009

3. (9 group sessions & patch)
Study Flow
225 participants expressing desire to quit smoking randomized at 5 methadone and 2 drug and alcohol abuse clinics
2:1
Smoking Cessation
(9 group sessions & patch) +
Substance Abuse TAU
N = 153
Substance Abuse TAU +
Post FU SC (offered)
N = 72
Completers
N = 142
Completers
N = 68
CTN-0009

4. Smoking Cessation in Outpatient Treatment
SC treatment reduced:
number of cigarettes smoked
breath CO levels
craving
CTN-0009

5. Smoking Cessation in Outpatient Treatment
Concurrent SC and AoD dependence treatment does not worsen AoD treatment outcomes
CTN-0009

6. Motivational Enhancement Therapy to Improve Treatment Utilization and Outcome in Pregnant Substance Users
Winhusen T, Kropp F, Babcock D, Hague D,
Erickson SJ, Renz C, Rau L, Lewis D,
Leimberger J, Somoza E.
Journal of Substance Abuse Treatment 2008
35(2):161-73
CTN-0013

7. Motivational Enhancement Therapy to Improve Treatment Utilization and Outcome in Pregnant Substance Users
Brief motivational interventions increase treatment engagement and improve outcomes in alcohol and drug abusing populations
CTN-0013 randomized clinical trial: Evaluate the efficacy of 3-session Motivational Enhancement Therapy (MET), compared to treatment as usual (TAU), in increasing treatment utilization and decreasing substance use in pregnant substance users
CTN-0013

8. Motivational Enhancement Therapy to Improve Treatment Utilization and Outcome in Pregnant Substance Users
Largest randomized clinical trial (n = 200, at 4 sites) with pregnant substance users
Primary outcome (treatment utilization): No differences between groups; 62% on average
Self-reported days of drug/ alcohol use: No differences between groups; significant decrease during first treatment month (Z=-2.40, p<.05)
CTN-0013

9. HIV/STD Safer Skills Groups for Women in Methadone Maintenance or Psychosocial Outpatient Treatment
Effectiveness of HIV/STD Sexual Risk Reduction Groups For Women In Substance Abuse Treatment Programs: Results Of NIDA Clinical Trials Network Trial
Susan Tross, Aimee Campbell, Lisa Cohen, Donald Calsyn,
Martina Pavlicova, Gloria Miele, Mei-Chen Hu, Louise Haynes,
Nancy Nugent, Weijin Gan, Mary Hatch-Maillette,
Raúl Mandler, Paul McLaughlin, Nabila El-Bassel,
Paul Crits-Cristoph, Edward Nuñes
Journal of Acquired Immune Deficiency Syndromes 2008
48(5):
CTN-0019

10. Study Design - RCT Baseline Assessment Eligibility
Cohort Randomization (n=515)
HIV Education (HE)
(1 Session)
Safer Sex Skills Building (SSB) (5 Sessions)
Post Treatment
3 Month FU
6 Month FU
CTN-0019

11. Observed (Baseline) and Predicted Means (3- and 6-Months) for USO
CTN-0019

12. Analysis of USO: Summary
Significant effect of SSB, as compared to HE, over time (E.S. = 0.42; p<0.0001) SSB had 29% fewer USOs than HE – at 6 months
While both interventions prompted initial decrease in USOs, only SSB sustained this decrease at 6 months
To maintain complex sexual risk behavior change among women, active, experiential and empowering interventions are needed
CTN-0019 12

13. Real World Implications (T3-Translation to Practice)
A brief, effective, gender-specific, skills-oriented sexual risk reduction intervention can be delivered by trained counselors at community drug treatment programs
The train-the-trainer model has particular promise for sustainability
Web-based technology versions of SSB may contribute in disseminating this effective intervention
CTN-0019

14. CTN’s Public Data Share www.ctndatashare.org
Fourteen studies currently posted for data share including studies on:
Buprenorphine (3)
Motivational Enhancement Therapy/Motivational Interviewing (4)
Contingency Management (2)
Community Treatment Program Surveys (2)
*****
HIV trials (3) will be posted by the end of 2008
Secondary Analysis

15. Published Secondary Analysis Using CTN’s Public Data Share

16. Secondary Analyses in Progress Using CTN’s Public Data Share
Gender differences in the prevalence and predictors of HIV risk behaviors, Audrey Brooks et al.
Pattern of alcohol use and alcohol-related diagnoses among drug abusing/dependent participants, Dennis Donovan et al.
The relationships between demographic characteristics of patients and therapists, measures of therapeutic process and therapeutic alliance, and outcomes, Alyssa Forcehimes et al.
Stimulant dependence symptom profiles among treatment-seeking stimulant users: a latent class analysis, Li-Tzy Wu et al.
An item response theory analysis of the DSM-IV checklist: a NIDA Clinical Trials Network study, Li-Tzy Wu et al.
An item response theory analysis of alcohol and marijuana dependence: a NIDA Clinical Trials Network study, Li-Tzy Wu et al.
Secondary Analysis