1. Metabolic Integration and Organ Specialization
Chapter 27
Metabolic Integration and Organ Specialization

2. Page 845
AMPK(AMP-activated protein kinase)

3. Page 845 CBS:cystathionine-b-synthase Thr172 Bateman doman 1

4. AMPK Controls Whole-Body Energy Homeostasis
Page 846
Metformin

5. Page 848

6. Page 848

7. During Prolonged Fasting or Starvation (in Brain)
Page 849

8. Page 849

9. In Muscle
Page 849 & 850

10. Page 850

11. Glucose and Lactate Are Transported in the Cori Cycle
Page 850

12. Fasting or Excessive Activity in Muscle
(The Glucose-Alanine Cycle Transfers Alanine to the Liver)
Page 851

13. Page 852
Thermogenin(uncoupling protein 1)

14. Page 852

15. Liver
Page 852
Glucokinase vs. Hexokinase

16. Metabolic Pathways for Glucose 6-phosphate in the Liver
Page 852

17. Metabolism of Fatty Acids in the Liver
Page 852

18. Metabolism of Amino Acids in the Liver
Page 853

19. The Hormones That Control Eating Behavior Come from
Many Different Tissues
Page 854
Orexic(appetite-stimulating) vs anorexic(appetite-suppressing)

20. Short-Term Eating Behavior Is Influenced by Ghrelin and PYY3-36
Page 937
(Lehn)
Ghrelin

21. Page 931
(Lehn)

22. Obesity Caused by Defective Leptin Production
Page 931
(Lehn)
*OB gene (leptin) & DB gene (diabetic; leptin receptor)
BMI(body mass index)=weight in kg/ (height in m)2

23. Page 933
(Lehn)

24. Insulin and Leptin Are Long-Term Regulators of
Eating Behavior
Page 934
(Lehn)

25. Page 934
(Lehn)
*AMP-dependent protein kinase (AMPK)

26. Page 935
(Lehn)

27. (Peroxisome Proliferator-activated Receptors) Page 936 (Lehn)
Mode of action of PPARs
(Peroxisome Proliferator-activated Receptors)
Page 936
(Lehn)
RXR: retinoid X receptor

28. Page 936
(Lehn)
Metabolic integration by PPARs

29. Sirt1 Is a Key Regulator in Caloric Restriction
(NAD+-dependent protein deacetylase)
Page 857
Deacetylated
-peptide

30. Sirt1 Is a Key Regulator in Caloric Restriction Page 857
Sir2(silent information regulator 2)
PGC-1(peroxisome proliferator-activator receptor- g coactivor-1)

31. Resveratrol, a Compound Found in Red Wine,
is a Potent Activator of Sirtuin Activity
Page 857

32. “Lipid Burden” Hypothesis for the Development of
Type 2 Diabetes Mellitus
Page 939
(Lehn)

33. Page 939
(Lehn)