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Strontium causes osteomalacia in chronic renal failure rats

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Presentation on theme: "Strontium causes osteomalacia in chronic renal failure rats"— Presentation transcript:

1 Strontium causes osteomalacia in chronic renal failure rats
Iris Schrooten, Walter Cabrera, William G. Goodman, Simonne Dauwe, Ludwig V. Lamberts, Rita Marynissen, Walter Dorriné, Marc E. De Broe, Patrick C. D’Haese  Kidney International  Volume 54, Issue 2, Pages (August 1998) DOI: /j x Copyright © 1998 International Society of Nephrology Terms and Conditions

2 Figure 1 Detailed time scheme of the experimental rat study. Abbreviations are: B, blood sampling for creatinine, Al, Sr, Ca, P, and iPTH; U, urine sampling for creatinine, Al, Sr, and Ca. Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

3 Figure 2 Goldner staining of a control (a), a Sr-loaded (b) and an Al-loaded rat (c). Note the increased amounts of osteoid in the Sr-loaded animal and the absence of osteoid in the Al-loaded rat. Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

4 Figure 3 Histological data of the various groups. *P < 0.05; **P < 0.01; ***P < Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

5 Figure 4 (left) Histochemical analysis of a histological bone section of a Sr-loaded rat. (a) Rhodizonate staining demonstrates the presence of Sr at the osteoid/calcification front (× 81). (b) Magnification (×202.5) clearly demonstrates the presence of small consecutive lines. (c) Schematic summary of the histochemical result. Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

6 Figure 5 (right) Electron probe X-ray microanalysis of a histological bone section of a Sr-loaded rat. (a) Ca (white) is homogeneously present in calcified bone. (b) Sr (yellow) could be demonstrated in calcified bone, with most of the Sr present near the mineralization front. (c) Schematic summary of the EPXMA analysis. Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

7 Kidney International 1998 54, 448-456DOI: (10. 1046/j. 1523-1755. 1998
Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

8 Kidney International 1998 54, 448-456DOI: (10. 1046/j. 1523-1755. 1998
Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions


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