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Figure 4 Laquinimod treatment suppresses development of spontaneous EAE Laquinimod treatment suppresses development of spontaneous EAE (A) 2D2 × Th mice.

Published bySuryadi Irawan Modified over 5 years ago

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Presentation on theme: "Figure 4 Laquinimod treatment suppresses development of spontaneous EAE Laquinimod treatment suppresses development of spontaneous EAE (A) 2D2 × Th mice."— Presentation transcript:

1 Figure 4 Laquinimod treatment suppresses development of spontaneous EAE
Laquinimod treatment suppresses development of spontaneous EAE (A) 2D2 × Th mice were treated with laquinimod (25 mg/kg) or vehicle (water) daily by oral gavage starting 19 days after birth (see arrow). Mice were examined once a day for onset of clinical EAE. The first quartile of mice that developed EAE is indicated since only 29% of laquinimod-treated mice developed disease throughout the observation period. Hazard ratio was determined using Cox regression with the Breslow method for ties. (B) Daily oral laquinimod treatment decreases the severity of spontaneous EAE in 2D2 × Th mice. Data represent the mean maximal scores of those mice that developed EAE. *p < 0.05, Mann-Whitney U test. EAE = experimental autoimmune encephalomyelitis; LAQ = laquinimod; Veh = vehicle. Michel Varrin-Doyer et al. Neurol Neuroimmunol Neuroinflamm 2016;3:e272 © 2016 American Academy of Neurology

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Figure 3 Test reliability of enzymatic dissociation methods
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