2. JRC support to EC work on endocrine disrupters
Elise Grignard
23 November 2018

3. throughout the whole policy cycle
Joint Research Centre's Mission
"
As the science and knowledge service of the Commission our mission is to support EU policies with independent evidence
throughout the whole policy cycle
"

4. EURL ECVAM
Established under Directive 2010/63/EU on the protection of animals used for scientific purposes
Integrating testing strategies/developing new risk assessment paradigms
(avoiding use of animals)
Validation of testing approaches
Dissemination and application:
Facilitating stakeholder dialogue
International promotion and regulatory acceptance (e.g.OECD)

5. JRC Activities on Endocrine Disrupters
Scientific criteria for the identification of endocrine disrupting substances
EAG: scientific aspects, end of 2011 until the Summer of MS representatives, NGOs, Industry. provide advice/orientation on key factors relevant to scientific criteria for the identification of endocrine disrupting substances, not specific to any regulatory framework
2) A second report related to the uncertainties in establishing thresholds of adversity for endocrine disruptors (low dose effects and NMDR)
3) collect and assess available evidence regarding endocrine disrupting effects of selected substances in a limited amount of time. The methodology was used to determine which of approximately 600 substances would be potentially categorised as ED under the following four policy options (about 10 months).

6. Priorities for new testing approaches
Workshop on setting priorities for further development and validation of test methods and testing approaches for evaluating endocrine disruptors – May 2017
Draft Detailed Review Paper on the retinoid system
Workshop on thyroid disruption – March 2017
Temporal aspects in the testing of chemicals for endocrine disrupting effects (in relation to human health and the environment) – Jan 2018

7. Priorities for new testing approaches
Development of a study protocol for thyroid disruptor testing in the mammalian system
Horizon

8. EU NETVAL Validation Study
EURL ECVAM: validation study to assess in vitro methods for the detection of thyroid disrupters
17 methods investigated by 14 laboratories of the EU-NETVAL (European Union Network of Laboratories for the Validation of Alternative Methods)

9. JRC Activities on Endocrine Disrupters

10. EURL ECVAM Status report - 2018 coming soon

11. Any questions?
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