1. Life-Threatening Chemotoxicity

3. Program Goals

4. Introduction

5. Tumor Lysis Syndrome

6. High-Dose MTX: Paradigm of Life-Threatening Chemotoxicity

7. HDMTX: Mechanism of Action

8. Uses of HDMTX

9. Toxicities Associated With HDMTX

10. HDMTX Toxicity: Risk Factors

11. HDMTX: Drug-Drug Interactions

12. Preventing HDMTX Toxicity

13. HDMTX: Dosing and Administration

14. LV Rescue

15. MTX Clearance

16. Case 1: Adult

17. Case 1: Adult (cont)

18. HDMTX: Management of Toxicity

19. Case 2: Adolescent

20. Case 3: Adolescent

21. Case 3: Adolescent (cont)

22. Glucarpidase: Mechanism of Action

23. HDMTX-Induced Renal Dysfunction: Effect of Early Intervention of Glucarpidase + LV

24. HDMTX: Multidisciplinary Care

25. HDMTX: Reinitiation After Toxicity

26. HDMTX: Reinitiation After Toxicity (cont)

27. Conclusions

28. Thank you for participating in this activity.