1. HIV and HLA Class I: An Evolving Relationship
Philip J.R. Goulder, Bruce D. Walker 
Immunity 
Volume 37, Issue 3, Pages (September 2012)
DOI: /j.immuni
Copyright © 2012 Elsevier Inc. Terms and Conditions

2. Figure 1
Defined HLA Class I and Class II Alleles by Year from 1968–2012
Graph taken from copyright SGE Marsh 07/2012, with permission.
Immunity  , DOI: ( /j.immuni )
Copyright © 2012 Elsevier Inc. Terms and Conditions

3. Figure 2
Potential Mechanisms of HLA-Associated Impact on Viral Control
The HLA class I molecule is a heterodimer consisting of three alpha helices and β-2 microglobulin. The alpha 1 and alpha 2 domains together form the peptide binding groove, which presents viral peptides at the surface of an infected cell, and this complex is in turn recognized by the T cell receptor on CD8+ T cells, through interactions with both the TCR and CD8 receptor (shown). The HLA molecule or peptide-HLA complex may also bind KIR and LILR (not shown). The mechanisms by which HLA and its interactions with CD8+ T cells, TCR, epitope, and infected cells, as well as HLA-specific mechanisms, have been shown to modulate the efficacy of HIV control are listed.
Immunity  , DOI: ( /j.immuni )
Copyright © 2012 Elsevier Inc. Terms and Conditions