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Michael P. Lilly, MD, Martha J. Brunner, PhD, Kurt E

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Presentation on theme: "Michael P. Lilly, MD, Martha J. Brunner, PhD, Kurt E"— Presentation transcript:

1 Jugular venous vasopressin increases during carotid endarterectomy after cerebral reperfusion 
Michael P. Lilly, MD, Martha J. Brunner, PhD, Kurt E. Wehberg, MS, Diane M. Rudolphi, BSN, Luis A. Queral, MD  Journal of Vascular Surgery  Volume 16, Issue 1, Pages 1-9 (July 1992) DOI: / (92)90410-A Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

2 Fig. 1 A, Jugular venous plasma vasopressin (n = 41) at five times during carotid endarterectomy: at the time of vascular exposure of the carotid artery (CONTROL), immediately after carotid clamping and shunt placement (OCCL no. 1), after carotid endarterectomy and immediately before shunt removal (CEA), immediately after shunt removal and reperfusion through the carotid lumen (OCCL no. 2) and before wound closure (CLOSE). Plasma vasopressin increased significantly at OCCL no. 2 and remained elevated above control at CLOSE (p < 0.001, ANOVA). B, Jugular venous plasma vasopressin grouped according to whether patients received phenylephrine (+ Phenylephrine, n = 18) or not (− Phenylephrine, n = 23). Greater increases in vasopressin were seen in patients who received phenylephrine (p < 0.025, ANOVA). *p < 0.05 versus control (ANOVA, NK); †p < 0.05 versus same time point (ANOVA, NK). Journal of Vascular Surgery  , 1-9DOI: ( / (92)90410-A) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

3 Fig. 2 A, Jugular venous plasma cortisol (n = 35) during carotid endarterectomy. The sampling times and symbols are described in Fig. 1. Plasma cortisol did not change during the sampling period. B, Jugular venous plasma cortisol grouped according to whether patients received phenylephrine (+ Phenylephrine, n = 16) or not (− Phenylephrine, n = 19). Although plasma cortisol did not change in either group, values were higher in the group receiving phenylephrine (p < 0.05, ANOVA). Journal of Vascular Surgery  , 1-9DOI: ( / (92)90410-A) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

4 Fig. 3 Jugular venous plasma ACTH (n = 17) during carotid endarterectomy. The sampling times and symbols are described in Fig. 1. Plasma ACTH did not change significantly during the sampling period. Journal of Vascular Surgery  , 1-9DOI: ( / (92)90410-A) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

5 Fig. 4 A, Mean arterial pressure (n = 41) during carotid endarterectomy. The sampling times and symbols are described in Fig. 1. Mean arterial pressure increased slightly over the sampling period (p < 0.05, ANOVA). B, Mean arterial pressure grouped according to whether patients received calcium channel blockers (+ CA blockers, n = 17) or did not (− Ca blockers, n = 24). Mean arterial pressure was significantly lower among patients receiving calcium channel blockers (p < 0.05, ANOVA). Journal of Vascular Surgery  , 1-9DOI: ( / (92)90410-A) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions


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