1. Network modules correspond to known and novel functional distinctions between neuronal subtypes.
Network modules correspond to known and novel functional distinctions between neuronal subtypes. Heat maps depicting expression of genes (rows) across all samples (columns) are shown for six selected modules: green (#4), red (#11), turquoise (#12), blue (#2), light yellow (#6), and pink (#9). The remaining modules are depicted in Supplementary Figure 1. Within the heat map, red corresponds to high expression and green corresponds to genes that are expressed at a low level. A weighted summary of gene expression (or the module eigengene) is shown below each heat map as a barplot. The black horizontal bar above the heat map denotes the association between the module and neuronal subtypes, and the significance of this association using the Kruskal–Wallis test is reported as the P‐value below the heat map. A map of the different neuronal subtypes across the heat maps is located in the upper left. (A) The green (#4) module contains 419 genes and corresponds to genes highly expressed in either glutamatergic or GABAergic neurons (P=2.9e−7). (B) The red (#11) module contains 263 genes in LGN interneurons (P=0.005). (C) The turquoise (#12) module contains 358 genes that are highly expressed in cingulate parvalbumin‐positive interneurons and layer V pyramidal neurons (P=9.1e−6). (D) The blue (#2) module contains 252 genes that are highly expressed in hippocampal somatostatin‐positive interneurons, cingulate parvalbumin‐positive interneurons, and layer V pyramidal neurons (P=1.6e−6). (E) The light yellow (#6) module contains 121 genes that are regulated specifically in telencephalic interneurons, but not other interneurons (P=4.3e−7). (F) The pink (#9) module contains 249 genes that are highly expressed in glutamatergic neurons and downregulated in somatostatin‐ and parvalbumin‐positive interneurons (P=3.0e−7).
Kellen D Winden et al. Mol Syst Biol 2009;5:291
© as stated in the article, figure or figure legend