1. Mechanisms of reduced susceptibility to amoxycillin-clavulanic acid in Escherichia coli strains from the health region of Tortosa (Catalonia, Spain) 
M.O. Pérez-Moreno, O. Katargina, M. Pérez-Moreno, M. Carulla, C. Rubio, A.M. Jardí, J. Zaragoza 
Clinical Microbiology and Infection 
Volume 10, Issue 3, Pages (March 2004)
DOI: /j X x
Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions

2. Fig. 1
Percentage of amoxycillin-clavulanic acid (A/C)-intermediate (MIC mg/L) or -resistant (MIC > mg/L) strains showing each of the different resistance phenotypes against β-lactams: phenotype HP, consistent with hyperproduction of TEM-1, TEM-2 or SHV-1 β-lactamases; phenotype C, consistent with AmpC cephalosporinase hyperproduction; phenotype P + C, consistent with AmpC cephalosporinase hyperproduction plus plasmid-encoded penicillinase production; phenotype IR, consistent with production of inhibitor-resistant penicillinase.
Clinical Microbiology and Infection  , DOI: ( /j X x)
Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions

3. Fig. 2
(a) Characteristics of β-lactamases produced by amoxycillin-clavulanic acid-intermediate strains (MIC mg/L) showing a resistance pattern consistent with inhibitor-resistant penicillinase production (phenotype IR). (b) Characteristics of β-lactamases produced by amoxycillin-clavulanic acid-resistant strains (MIC ≥ mg/L) showing a resistance pattern consistent with inhibitor-resistant penicillinase production (phenotype IR).
Clinical Microbiology and Infection  , DOI: ( /j X x)
Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions

4. Fig. 3
Inferred prevalence of the different mechanisms of resistance among the 158 E. coli isolates with reduced susceptibility to amoxycillin-clavulanic acid (A/C), based on resistance patterns and phenotypic β-lactamase characterisation combined: PEN-H, overproduction of TEM-1, TEM-2 or SHV-1 β-lactamases; IRT, production of presumptive IRT β-lactamases; OXA-1, production of a β-lactamase co-focusing with OXA-1 + production of a β-lactamase co-focusing with TEM-1; PSE-1, production of a β-lactamase co-focusing with PSE-1 + production of a β-lactamase co-focusing with TEM-1; CASE-H, hyperproduction of AmpC cephalosporinase + production of plasmid-encoded penicillinase; UM, unknown mechanism.
Clinical Microbiology and Infection  , DOI: ( /j X x)
Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions