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Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk  E.Jan Irvine, John K. Marshall  Gastroenterology 

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Presentation on theme: "Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk  E.Jan Irvine, John K. Marshall  Gastroenterology "— Presentation transcript:

1 Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk  E.Jan Irvine, John K. Marshall  Gastroenterology  Volume 119, Issue 6, Pages (December 2000) DOI: /gast Copyright © 2000 American Gastroenterological Association Terms and Conditions

2 Fig. 1 (A) Single- and (B) double-contrast views of the terminal ileum of the patient at age 21 show several features of Crohn's ileitis: separation of loops (short arrows), antimesenteric scalloping (long arrows), stricture with linear ulceration (curved arrow), and an ulceronodular mucosal relief pattern (open arrow). Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

3 Fig. 2 Intestinal permeability of the study cohort. Results are expressed as the percentage of an oral dose of 51Cr-EDTA excreted in the urine over 24 hours (upper limit of normal, 2.3%). The urinary excretion value for the index case is highlighted (arrow). Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions


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