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Innate Immune DNA-Sensing Pathways

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Presentation on theme: "Innate Immune DNA-Sensing Pathways"— Presentation transcript:

1 Innate Immune DNA-Sensing Pathways
Cell  Volume 152, Issue 3, (January 2013) DOI: /j.cell Copyright © Terms and Conditions

2 cGAS interacts with DNA in the cytosol. Image courtesy of Zhijian Chen.
Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions

3 In phagocytes, the TLR9-UNC93B complex (yellow) migrates to engulfed DNA-IgG-coated beads. Image courtesy of Miguel Sanjuanm. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions

4 TRIM21 negatively regulates DDX41-dependent innate responses to DNA viruses. Image courtesy of iStock/Henrik5000. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions

5 Trex1 deficiency causes an expanded lysosomal compartment in fibroblasts. Image courtesy of Nan Yan.
Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions


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