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National Cancer Institute, National Heart, Lung and Blood Institute/Pediatric Blood and Marrow Transplantation Consortium First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation: The Need for Pediatric- Specific Long-Term Follow-up Guidelines Michael A. Pulsipher, Roderick Skinner, George B. McDonald, Sangeeta Hingorani, Saro H. Armenian, Kenneth R. Cooke, Clarisa Gracia, Anna Petryk, Smita Bhatia, Nancy Bunin, Michael L. Nieder, Christopher C. Dvorak, Lillian Sung, Jean E. Sanders, Joanne Kurtzberg, K. Scott Baker Biology of Blood and Marrow Transplantation Volume 18, Issue 3, Pages (March 2012) DOI: /j.bbmt Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 1 Late effects after HCT are a result of the interaction of pre-HCT exposures to chemotherapy, radiation, and surgery with the transplantation conditioning regimen, acute complications of transplantation, and transplantation-specific complications, such as acute and chronic GVHD, persistent immunodeficiency, and so on. The risks for these outcomes are also modified by other intrinsic and extrinsic factors (age, sex, genetics, social, comorbidities, lifestyle) that can alter these risks in either a positive or a negative manner. Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions
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