1. Rapamycin inhibits TCR/CD3 engagement-dependent HIF-1α protein expression.
Rapamycin inhibits TCR/CD3 engagement-dependent HIF-1α protein expression. Human peripheral blood T cells were incubated for 12 h in the absence or presence of various concentrations of rapamycin (10 nM in A, and 0.5, 1, 5, and 10 nM in B), or anti-CD3 mAb (CD3) under hypoxic conditions (1% O2), and HIF-1α or β-actin were detected in immunoblots.
Hiroshi Nakamura et al. J Immunol 2005;174:
Copyright © 2005 by The American Association of Immunologists