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Combined use of cerebral spinal fluid drainage and naloxone reduces the risk of paraplegia in thoracoabdominal aneurysm repair  C.W. Acher, MD, M.M. Wynn,

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Presentation on theme: "Combined use of cerebral spinal fluid drainage and naloxone reduces the risk of paraplegia in thoracoabdominal aneurysm repair  C.W. Acher, MD, M.M. Wynn,"— Presentation transcript:

1 Combined use of cerebral spinal fluid drainage and naloxone reduces the risk of paraplegia in thoracoabdominal aneurysm repair  C.W. Acher, MD, M.M. Wynn, MD, J.R. Hoch, MD, P. Popic, MD, Judy Archibald, RN, W.D. Turnipseed, MD  Journal of Vascular Surgery  Volume 19, Issue 2, Pages (February 1994) DOI: /S (94) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 2 Bivariate plot of actual versus estimated number of deficits in 16 series of TAA repair. Very high correlation (correlation coefficient 0.997, p < 0.001) and no statistical difference between actual and estimated (paired t test p = , mean difference = 0.059) number of deficits lend strength to our conclusions that group A had significantly improved results for risk of deficit over group B and that clinical presentation and extent of aorta replaced are primary factors for deficit risk. Journal of Vascular Surgery  , DOI: ( /S (94) ) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 1 A, With repeated measures ANOVA patients with acute aneurysms were warmer, had acidosis, and had lower blood pressure than patients undergoing elective procedures. B, However, patients in group A and B had no significant difference in these variables. These physiologic data do not account for significant difference in number of deficits between patients with acute aneurysms (10 deficits) and patients undergoing elective procedures (2 deficits) or between acute group A (1 deficit) and B (9 deficits). Journal of Vascular Surgery  , DOI: ( /S (94) ) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

4 Fig. 3 Plot of actual versus predicted number of deficits for group B subgroups and group A. By our predictive model group B subgroups: naloxone only, CSFD only, and neither CSFD or naloxone were consistent with each other for deficit risk. Group A had significantly fewer deficits than predicted. Journal of Vascular Surgery  , DOI: ( /S (94) ) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions


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