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Impact of induction chemoradiotherapy on pulmonary function after lobectomy for lung cancer  Hiroaki Nomori, MD, Atsushi Shiraishi, MD, Yue Cong, MD,

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Presentation on theme: "Impact of induction chemoradiotherapy on pulmonary function after lobectomy for lung cancer  Hiroaki Nomori, MD, Atsushi Shiraishi, MD, Yue Cong, MD,"— Presentation transcript:

1 Impact of induction chemoradiotherapy on pulmonary function after lobectomy for lung cancer 
Hiroaki Nomori, MD, Atsushi Shiraishi, MD, Yue Cong, MD, Kazufusa Shoji, MD, Masafumi Misawa, MD, Hiroshi Sugimura, MD, Yu Oyama, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 155, Issue 5, Pages e1 (May 2018) DOI: /j.jtcvs Copyright © 2017 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Patient algorithm used in the study. ICRT, Induction chemoradiotherapy. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2017 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Percentages of postoperative versus preoperative whole-lung function in the induction chemoradiotherapy (ICRT) and non-ICRT groups. The postoperative change of whole-lung function, evaluated from the formula %FEV1 in PFT after surgery/%FEV1 before surgery. Red indicates the postoperative change of whole-lung function in ICRT group, and blue indicates the postoperative change of whole-lung function in non-ICRT group. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2017 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Δ% forced expiratory volume in 1 second (FEV1) of the ipsilateral preserved lobe after surgery in the induction chemoradiotherapy (ICRT) and non-ICRT groups. The postoperative change of whole-lung function, evaluated from the formula %FEV1 in PFT after surgery/%FEV1 before surgery. Red indicates the postoperative change of whole-lung function in ICRT group, and blue indicates the postoperative change of whole-lung function in non-ICRT group. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2017 The American Association for Thoracic Surgery Terms and Conditions

5 Figure 4 Preoperative and postoperative percentage of forced expiratory volume in 1 second (FEV1) values of the contralateral lung in the induction chemoradiotherapy (ICRT) and non-ICRT groups. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2017 The American Association for Thoracic Surgery Terms and Conditions

6 Figure 5 Δ% forced expiratory volume in 1 second (FEV1) of the contralateral lung after surgery in the induction chemoradiotherapy (ICRT) and non-ICRT groups. The postoperative change of whole-lung function, evaluated from the formula %FEV1 in PFT after surgery/%FEV1 before surgery. Red indicates the postoperative change of whole-lung function in ICRT group, and blue indicates the postoperative change of whole-lung function in non-ICRT group. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2017 The American Association for Thoracic Surgery Terms and Conditions

7 Figure 6 Sensitivity analyses for potential confounders. Intergroup comparison of the primary outcome after propensity score matching (original model) was further adjusted for each potential confounder (model B-I) and all potential confounders (model J). Estimates are shown in mean difference with 95% confidence intervals. %FEV1, Percentage of predicted forced expiratory volume in 1 second. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2017 The American Association for Thoracic Surgery Terms and Conditions

8 Figure E1 Absolute standardized mean differences between the control group and chemoradiotherapy group before and after matching. FEV1, Forced expiratory volume in 1 second; FVC, forced vital capacity. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2017 The American Association for Thoracic Surgery Terms and Conditions

9 Figure E2 Distribution of the propensity score in the induction chemoradiotherapy (ICRT) as well as the non-ICRT groups before and after matching is shown as a histogram per 5% propensity score steps; white bars, before the matching; red bars, after the matching. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2017 The American Association for Thoracic Surgery Terms and Conditions

10 The field received 20 Gy or more (purple line) for left upper lobe cT2aN2M0 cancer.
The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2017 The American Association for Thoracic Surgery Terms and Conditions

11 Video 1 Left upper lobectomy after induction chemoradiotherapy. Video available at: The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2017 The American Association for Thoracic Surgery Terms and Conditions

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