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Clifford J. Holmes, Dirk Faict  Kidney International 

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Presentation on theme: "Clifford J. Holmes, Dirk Faict  Kidney International "— Presentation transcript:

1 Peritoneal dialysis solution biocompatibility: Definitions and evaluation strategies 
Clifford J. Holmes, Dirk Faict  Kidney International  Volume 64, Pages S50-S56 (December 2003) DOI: /j x Copyright © 2003 International Society of Nephrology Terms and Conditions

2 Figure 1 A hierarchical representation of biocompatibility testing. The progression from in vitro to clinical studies usually results in a level of increasing clinical relevance, with a corresponding increase in the demand of expertise and resources. Kidney International  , S50-S56DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

3 Figure 2 A contemporary model of peritoneal membrane dysfunction that provides detail of potential effectors and mediators of structural and function membrane alteration in the long-term patient. The corresponding contribution of in vitro and animal model biocompatibility methods to each aspect of the model is provided. Modified from Miyata et al: Kidney Int 61:375–386, 2002. Kidney International  , S50-S56DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

4 Figure 3 A contemporary model of peritoneal membrane dysfunction that provides detail of potential effectors and mediators of structural and function membrane alteration in the long-term patient. The corresponding contribution of clinical studies of in vivo response and membrane function to each aspect of the contemporary model membrane dysfunction is provided. Modified from Miyata et al: Kidney Int 61:375–386, 2002. Kidney International  , S50-S56DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions


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