1. JAK1 Takes a FERM Hold of Type II Cytokine Receptors
Jeffrey J. Babon, Nicholas P.D. Liau, Nadia J. Kershaw 
Structure 
Volume 24, Issue 6, Pages (June 2016)
DOI: /j.str
Copyright © 2016 Elsevier Ltd Terms and Conditions

2. Figure 1 A Model of the JAK:Receptor Interaction
On the left, the structure of JAK1 bound to box1 from the IFNλ receptor (PDB: 5IXD (Ferrao et al., 2016)) is shown overlaid with the box2 motif from the IFNα receptor (PDB: 4PO6 (Wallweber et al., 2014)). The PxxLxF motif within box1 identified by Ferrao et al. (2016) is shown with the sidechains colored white. Although box1 and box2 occupy non-overlapping, nearly continuous binding sites, they have not yet both been observed in the one structure. On the right is a schematic of a full-length JAK/Receptor interaction. For clarity, only one receptor chain and associated JAK is shown. The boxed region corresponds to the structural model shown on the left.
Structure  , DOI: ( /j.str )
Copyright © 2016 Elsevier Ltd Terms and Conditions