1. PARP-1, a determinant of cell survival in response to DNA damage
Véronique J. Bouchard, Michèle Rouleau, Guy G. Poirier 
Experimental Hematology 
Volume 31, Issue 6, Pages (June 2003)
DOI: /S X(03)

2. Figure 1
Structure of PARP-1. PARP-1 can be divided in 3 main domains: a DNA-binding domain (DBD) with 2 zinc fingers (Zn I and Zn II), an automodification domain with a BRCT motif, and a catalytic domain with the NAD+-binding site. The nuclear localization signal (NLS) is located between the DBD and the automodification domain. It comprises the DEVD cleavage site recognized by caspases 3 and 7.
Experimental Hematology  , DOI: ( /S X(03) )

3. Figure 2
Model for DNA damage signaling by PARP-1. PARP-1 binds on DNA strand breaks and is activated. It then modifies factors to induce a cell cycle arrest and allow DNA repair. In case of massive DNA damage, PARP-1 can deplete the NAD+ pool and induce necrosis or send an apoptotic signal.
Experimental Hematology  , DOI: ( /S X(03) )