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Late Mortality and Causes of Death among Long-Term Survivors after Allogeneic Stem Cell Transplantation Yoshiko Atsuta, Akihiro Hirakawa, Hideki Nakasone, Saiko Kurosawa, Kumi Oshima, Rika Sakai, Kazuteru Ohashi, Satoshi Takahashi, Takehiko Mori, Yukiyasu Ozawa, Takahiro Fukuda, Heiwa Kanamori, Yasuo Morishima, Koji Kato, Hiromasa Yabe, Hisashi Sakamaki, Shuichi Taniguchi, Takuya Yamashita Biology of Blood and Marrow Transplantation Volume 22, Issue 9, Pages (September 2016) DOI: /j.bbmt Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 1 (A) The probabilities of overall survival among relapse-free survivors at 2 years after HCT were 93% at 5 years, 87% at 10 years, and 83% at 15 years. (B) Cumulative incidence of cause-specific mortality at 10 years was 3.7% for death due to recurrent disease, 2.4% for infection, 1.3% for secondary malignancy, and 2.5% for respiratory disease. Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 2 (A) Overall mortality rates (solid circles) are shown with fitted rates from the smoothing spline Poisson regression model (solid line) and associated point-wise 95% CIs (short-dashed line). Annual expected mortality rates are based on sex-, age-, and calendar year (5 years)-specific data in Japan (dotted line). (B) Mortality rates due to infection (black open square), non-hematologic new malignancy (red open circle), respiratory (blue open diamond), liver (aqua open inverted triangle) and kidney-genitourinary (purple cross) are shown with the corresponding fitted rates from the smoothing spline Poisson regression model. It should be noted that the annual expected mortality rates for each cause are not shown since all were less than .001. Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions
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