1. Refinement quantity and quality

2. How to Achieve Higher Throughput and Maintain Quality & Consistency
New People for refinement and QC
New / improved tools to streamline the process
Increased automation
Improved documentation -- Standards

3. Goals for Structures Accurate Conservative – don’t over interpret
Build complete structures
Automation & standardization
Data quality
Efficient / fast

4. Goals for QC Ensures standards are applied uniformly
Provides a second opinion

5. Comparison of R and R-free
R-factor
R-free

6. Improved Documentation

7. New Refinement Summary Document
A refinement summary is prepared for each target.
Puts structure in context
1) Overall rating 2) Structure overview 3) Sequence comparisons 4) Structural comparisons 5) Ligand description 6) Literature

8. New Tools -- Refinement Checkout

10. New Tools – Automated QC checks

11. QC Check Results R/R-free analysis Nominal Resolution Map correlation
Refinement protocol (NCS, TLS, etc)
Sequence
Nomenclature

12. Structures in Refinement/QC by date

13. Time to Deposition by Year
Year Solved

14. Phasing to Deposition by Resolution

16. Increasing Throughput
New Refiners
New QC checks
Improved automation / model completion
Standardization