Presentation is loading. Please wait.

Presentation is loading. Please wait.

Refinement quantity and quality

Similar presentations


Presentation on theme: "Refinement quantity and quality"— Presentation transcript:

1 Refinement quantity and quality

2 How to Achieve Higher Throughput and Maintain Quality & Consistency
New People for refinement and QC New / improved tools to streamline the process Increased automation Improved documentation -- Standards

3 Goals for Structures Accurate Conservative – don’t over interpret
Build complete structures Automation & standardization Data quality Efficient / fast

4 Goals for QC Ensures standards are applied uniformly
Provides a second opinion

5 Comparison of R and R-free
R-factor R-free

6 Improved Documentation

7 New Refinement Summary Document
A refinement summary is prepared for each target. Puts structure in context 1) Overall rating 2) Structure overview 3) Sequence comparisons 4) Structural comparisons 5) Ligand description 6) Literature

8 New Tools -- Refinement Checkout

9

10 New Tools – Automated QC checks

11 QC Check Results R/R-free analysis Nominal Resolution Map correlation
Refinement protocol (NCS, TLS, etc) Sequence Nomenclature

12 Structures in Refinement/QC by date

13 Time to Deposition by Year
Year Solved

14 Phasing to Deposition by Resolution

15

16 Increasing Throughput
New Refiners New QC checks Improved automation / model completion Standardization

17

18


Download ppt "Refinement quantity and quality"

Similar presentations


Ads by Google