1. Blood Testing for Differential Diagnosis of Pulmonary Alveolar Proteinosis Syndrome 
Cormac McCarthy, MD, PhD, Brenna Carey, PhD, Bruce C. Trapnell, MD 
CHEST 
Volume 155, Issue 2, Pages (February 2019)
DOI: /j.chest
Copyright © 2018 American College of Chest Physicians Terms and Conditions

2. Figure 1
Diagnostic testing in patients with pulmonary alveolar proteinosis (PAP) syndrome. A, Percentages of patients with aPAP (n = 56) in the US National PAP Registry who underwent surgical biopsy, transbronchial lung biopsy, or both during their diagnostic evaluation.3 B, Serum GM-CSF autoantibody testing in patients with aPAP, hPAP, sPAP, or cPAP, patients with OLD, and HC. Red lines indicate the mean value within each group. The dotted line is the threshold cutoff value determined by receiver operating characteristic curve analysis.3 Values above the gray bar are interpreted as abnormal, whereas values below it are interpreted as normal. The gray bar represents the range of values that is sufficiently close to the cutoff to warrant additional testing if clinically indicated. aPAP = autoimmune PAP; cPAP = congenital PAP; GM-CSF = granulocyte/macrophage-colony stimulating factor; HC = healthy control individuals; hPAP = hereditary PAP; OLD = other lung diseases; sPAP = secondary PAP.
CHEST  , DOI: ( /j.chest )
Copyright © 2018 American College of Chest Physicians Terms and Conditions