1. Peripheral lidocaine but not ketamine inhibits capsaicin-induced hyperalgesia in humans 
H. Gottrup, F.W. Bach, L. Arendt-Nielsen, T.S. Jensen 
British Journal of Anaesthesia 
Volume 85, Issue 4, Pages (October 2000)
DOI: /bja/
Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

2. Fig 1
Spontaneous pain intensity plotted as mean VAS pain score±sem. Pain was reduced by pretreating the capsaicin injection site with local s.c. infiltration of lidocaine (a), but s.c. infiltration of ketamine (b) did not reduce pain (ANOVA RM, P<0.001; P<0.05 lidocaine vs saline).
British Journal of Anaesthesia  , DOI: ( /bja/ )
Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

3. Fig 2
Brush-evoked pain intensity plotted as mean VAS pain score±sem. Pain was reduced by pretreating the capsaicin injection site with local s.c. infiltration of lidocaine (a), but s.c. infiltration of ketamine (b) did not reduce pain (ANOVA RM, P<0.001; P<0.05 lidocaine vs saline).
British Journal of Anaesthesia  , DOI: ( /bja/ )
Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

4. Fig 3
Punctate-evoked pain intensity plotted as mean VAS pain score±sem. Pain was reduced by pretreating the capsaicin injection site with local s.c. infiltration of lidocaine (a), but s.c. infiltration of ketamine (b) did not reduce pain (ANOVA RM, P<0.001; P<0.05 lidocaine vs saline).
British Journal of Anaesthesia  , DOI: ( /bja/ )
Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

5. Fig 4
The area of brush-evoked hyperalgesia (mean±sem) was reduced by pretreatment of the capsaicin injection site with local s.c. infiltration of lidocaine (a), but s.c. infiltration of ketamine (b) did not reduce the area (ANOVA RM, P<0.001; P<0.05 lidocaine vs saline).
British Journal of Anaesthesia  , DOI: ( /bja/ )
Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

6. Fig 5
The area of punctate-evoked hyperalgesia (mean±sem) was reduced by pretreating the capsaicin injection site with local s.c. infiltration of lidocaine (a), but s.c. infiltration of ketamine (b) did not reduce the area (ANOVA RM, P<0.001; P<0.05 lidocaine vs saline).
British Journal of Anaesthesia  , DOI: ( /bja/ )
Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

7. Fig 6
The effects of local infiltration of lidocaine and ketamine contralateral to the capsaicin injection site on VAS pain scores (mean±sem). Placebo (saline) was injected at the capsaicin injection site. (a) Spontaneous pain. (b) Brush-evoked pain. (c) Punctate-evoked pain.
British Journal of Anaesthesia  , DOI: ( /bja/ )
Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

8. Fig 7
The effects of local s.c. infiltration of lidocaine and ketamine contralateral to the capsaicin injection site on the area of hyperalgesia (mean±sem). Placebo (saline) was injected at the capsaicin injection site. (a) Brush-evoked hyperalgesia. (b) Punctate-evoked hyperalgesia.
British Journal of Anaesthesia  , DOI: ( /bja/ )
Copyright © 2000 British Journal of Anaesthesia Terms and Conditions