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MARIAMMA G. JOSEPH, M.D.  Mayo Clinic Proceedings 

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1 Multiple Cystic Fibrohistiocytic Tumors of the Lung: Report of Two Cases 
MARIAMMA G. JOSEPH, M.D.  Mayo Clinic Proceedings  Volume 65, Issue 2, Pages (February 1990) DOI: /S (12) Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions

2 Fig. 1 (case 1). Chest roentgenogram (A) and computed tomogram (B) obtained in 1986, showing small bilateral pulmonary nodules, the largest located in left lower lobe. Mayo Clinic Proceedings  , DOI: ( /S (12) ) Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions

3 Fig. 2 (case 1). Chest roentgenogram obtained in 1988, showing scarring related to prior biopsies and bilateral pulmonary nodules slightly increased in size since 1986. Mayo Clinic Proceedings  , DOI: ( /S (12) ) Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions

4 Fig. 3 (case 2). Chest roentgenogram obtained in 1969, showing total left pneumothorax, thin-walled cysts in right lung, and solid and cystic lesions in collapsed left lung. Mayo Clinic Proceedings  , DOI: ( /S (12) ) Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions

5 Fig. 4 (case 2). Chest roentgenogram obtained in 1974, showing multiple thin-walled cysts in right lung (one with an air-fluid level) and a left-sided solid and cystic lesion. Mayo Clinic Proceedings  , DOI: ( /S (12) ) Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions

6 Fig. 5 (case 2). Chest roentgenogram (A) and computed tomogram (B) obtained in 1988, showing increase in size of right-sided cysts and a solid mass near each hilum. Mayo Clinic Proceedings  , DOI: ( /S (12) ) Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions

7 Fig. 6 (case 1). Photomicrographs of biopsy specimens. A, Note pleural and subpleural spindle cell proliferation with central cystic change, hemorrhage, and cholesterol clefts (arrows). B, Spindle cell foci are composed of fibrohistiocytic cells with a vague storiform pattern, identical to that seen in cutaneous fibrous histiocytoma. (Hematoxylin-eosin.) Mayo Clinic Proceedings  , DOI: ( /S (12) ) Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions

8 Fig. 7 (case 2). Thin-walled cyst (A) is lined by flattened squamous cells (B). Focally in wall of cyst (arrow in A), fibrohistiocytic proliferation was seen (C), identical to that in Figure 6 B. Proliferation grew interstitially and surrounded airspaces, which were lined by metaplastic cells. (Hematoxylin-eosin.) Mayo Clinic Proceedings  , DOI: ( /S (12) ) Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions


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