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Acute reductions in mechanical wall strain precede the formation of intimal hyperplasia in a murine model of arterial occlusive disease  John T. Favreau,

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Presentation on theme: "Acute reductions in mechanical wall strain precede the formation of intimal hyperplasia in a murine model of arterial occlusive disease  John T. Favreau,"— Presentation transcript:

1 Acute reductions in mechanical wall strain precede the formation of intimal hyperplasia in a murine model of arterial occlusive disease  John T. Favreau, ME, Chengwei Liu, MD, PhD, Peng Yu, MD, PhD, Ming Tao, MD, Christine Mauro, MD, Glenn R. Gaudette, PhD, C. Keith Ozaki, MD  Journal of Vascular Surgery  Volume 60, Issue 5, Pages (November 2014) DOI: /j.jvs Copyright © 2014 Society for Vascular Surgery Terms and Conditions

2 Fig 1 Study design. A focal stenosis (green arrow) was made in the left common carotid artery (LCCA) 1 mm proximal to the carotid bifurcation. Mechanical (via ultrasound) and histologic parameters were assessed 1, 2, and 3 mm proximal to the focal stenosis on the left side and in corresponding locations on the contralateral side (blue lines). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Regional differences in strain. Wall strains were assessed on the left (partially stenosed) common carotid artery (LCCA) and the right (unaltered) common carotid artery (RCCA) in the regions shown in Fig 1. The average for each side indicates the average of all regions. No differences amongst spatial locations were found on either side at any time point. The asterisks indicate P value of <.05 compared with preoperative values. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Morphologic analysis of day-28 carotid arteries. A, The intimal thickness of the distal left common carotid artery (LCCA) was significantly higher than that of the right common carotid artery (RCCA) at the same location. B, LCCA tends to have higher wall thickness than its counterpart RCCA. C, Representative histology for each of the three regions on the LCCA and RCCA. The daggers indicate P value of <.05 compared with the RCCA value at the same cross-sectional location. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

5 Fig 4 Changes in lumen area at (A) diastole and (B) systole. The asterisks indicate P value of <.05 compared with preoperative values. LCCA, Left common carotid artery; RCCA, right common carotid artery. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

6 Fig 5 Differences in distal left common carotid artery (LCCA) regions with low (<0.1) and high (>0.1) day-4 strain values. A, Histogram analysis showing the distribution of strain values among regions with cut-off value. B, Histologic outcome of LCCA regions with low and high strain. The double daggers indicate P value of <.05 vs low strain values. C, Changes in LCCA area at diastole over time in low- and high-strain groups. D, Changes in LCCA area at systole over time in low- and high-strain groups. E, Linear fit between wall strain at day 4 and intimal thickness at day 28. The asterisks indicate P value of <.05 compared with preoperative values. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

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