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Changes in Cerebral Vascular Reactivity Occur Early During Cardiopulmonary Bypass in the Rat  Thomas Modine, MD, Richard Azzaoui, MD, Thavarak Ouk, PhD,

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Presentation on theme: "Changes in Cerebral Vascular Reactivity Occur Early During Cardiopulmonary Bypass in the Rat  Thomas Modine, MD, Richard Azzaoui, MD, Thavarak Ouk, PhD,"— Presentation transcript:

1 Changes in Cerebral Vascular Reactivity Occur Early During Cardiopulmonary Bypass in the Rat 
Thomas Modine, MD, Richard Azzaoui, MD, Thavarak Ouk, PhD, Georges Fayad, MD, Dominique Lacroix, MD, PhD, Henri Warembourg, MD, Regis Bordet, MD, PhD, Terence Gourlay, PhD  The Annals of Thoracic Surgery  Volume 82, Issue 2, Pages (August 2006) DOI: /j.athoracsur Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Arterial pressure in the cardiopulmonary bypass (CPB) and sham groups of animals. The mean femoral arterial pressures were not significantly different between the groups. The data are expressed as mean ± SD. (Triangles = carotid CPB; diamonds = carotid sham; squares = femoral CPB; circles = femoral sham.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Blood gas data in the cardiopulmonary bypass (CPB) and sham arms of the study. Both PaO2and PaCO2 are shown, and there were no statistically significant differences between the groups in terms of either factor. (Diamonds = carotid PaO2; triangles = caudal PaO2; squares = carotid PaCO2; X = caudal PaCO2; post-op = postoperative; pre-op = preoperative; T = time.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 The myogenic tonus response in middle cerebral arteries, the contractile response to incrementally increasing transmural pressure (TMP), did not illicit any statistically significant differences between the groups. The data are expressed as mean ± SD and represent the percent (%) change in the precontracted tonus. (Squares = cardiopulmonary bypass [CPB] 30 minutes; diamonds = sham CPB 30 minutes; triangles = CPB 60 minutes; circles = sham CPB 60 minutes.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 The response of precontracted middle cerebral artery to acetylcholine (ACHOL [endothelium-dependent vasoreactivity]). The results are shown as mean ± SD and represent the percent (%) relaxation of serotonin-induced preconstriction. The degree of relaxation was substantially diminished in the cardiopulmonary bypass (CPB) group, confirming an alteration in dependent vasoreactivity. (conc = concentration; gray boxes = CPB 30 minutes; black triangles = CPB 60 minutes; gray triangles = sham 30 minutes; black boxes = sham 60 minutes.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Plasma tumor necrosis factor-α (TNFα) plasma concentration in the cardiopulmonary bypass (CPB) and sham groups. The CPB groups were associated with higher terminal levels. There was no significant difference between the CPB groups at termination, suggesting that the response occurs early in the CPB period. (Diagonal stripe bar = CPB 30 minutes; vertical stripe bar = CPB 60 minutes; open bar = sham 30 minutes; gray bar = sham 60 minutes.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

7 Fig 6 Immunohistochemical analysis of brain sections. (a) Sections from the sham rats display the vascular wall with low intensity staining. (b) In contrast, cardiopulmonary bypass was associated with a significant enhancement of vascular wall staining in the 30-minute cardiopulmonary bypass (T30 CPB) group. (c) The negative control (sacrificed animals) shows no staining for intercellular adhesion molecule-1. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

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