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Toward a New Twist in Hox and TALE DNA-Binding Specificity

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Presentation on theme: "Toward a New Twist in Hox and TALE DNA-Binding Specificity"— Presentation transcript:

1 Toward a New Twist in Hox and TALE DNA-Binding Specificity
Samir Merabet, Ingrid Lohmann  Developmental Cell  Volume 32, Issue 3, Pages (February 2015) DOI: /j.devcel Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Consensus and Non-Consensus Nucleotide Sequences in Hox/TALE DNA-Binding Specificity (A) Three different types of consensus binding sites are preferentially recognized by Hox/TALE complexes in vitro. Crystal structures showed a predominant role of the hexapeptide (HX) motif for complex formation on the consensus sequences. (B) Nucleotide sequences of atypical binding sites recognized by Ubx/TALE or AbdA/TALE complexes on characterized native enhancers in Drosophila. The UbdA (UA) motif is known to be important for association with TALE cofactors on the Distalless repressor element (DllR) (Merabet, and Hudry, 2013). Motif(s) required for the interaction with TALE cofactors on the other enhancers are not known (question marks). Note that AbdA could also form DNA-binding complexes with TALE cofactors on E3N and DllR. The topology of Meis binding sites is speculative on E,3N. (C) Nucleotide sequences (Hox-PBC and/or Hox together with Meis) of most frequent sites found in regions of synergistic binding of Meis, and Hoxa2, in the IIBA. The dotted arrows show possible interaction. Note that the consensus binding site for PBC is also not complete. High- and low-affinity binding sites are highlighted by large or thin boxes, respectively. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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