1. Ischemia-Driven Expression of CD73 Confers Tissue Protection During Liver Ischemia/Reperfusion 
Charles C. Caldwell, Alex B. Lentsch 
Gastroenterology 
Volume 135, Issue 5, Pages (November 2008)
DOI: /j.gastro
Copyright © 2008 AGA Institute Terms and Conditions

2. Figure 1
Depiction of the generation and termination of purine signaling. Extracellular ATP is increased under ischemic conditions and can signal through P2 ATP receptors. ATP is sequentially hydrolyzed to adenosine which can signal through P1 adenosine receptors. This signal is terminated by the reuptake of adenosine through its channel or by conversion to inosine by adenosine deaminase (ADA). CD39, ecto-NTP/Dase; CD73, ecto-5′-nucleotidase; Ado, adenosine; Ino, inosine.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2008 AGA Institute Terms and Conditions

3. Figure 2
IP results in increased CD73 expression. This increases extracellular adenosine, which blocks complement production. Decreased complement results in diminished I/R injury.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2008 AGA Institute Terms and Conditions