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Significant Enhancement of Esophageal Pre-Epithelial Defense by Tegaserod: Implications for an Esophagoprotective Effect  Marek Majewski, Tomasz Jaworski,

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Presentation on theme: "Significant Enhancement of Esophageal Pre-Epithelial Defense by Tegaserod: Implications for an Esophagoprotective Effect  Marek Majewski, Tomasz Jaworski,"— Presentation transcript:

1 Significant Enhancement of Esophageal Pre-Epithelial Defense by Tegaserod: Implications for an Esophagoprotective Effect  Marek Majewski, Tomasz Jaworski, Irene Sarosiek, Sandra Sostarich, Katherine Roeser, Stanley A. Edlavitch, Jeffrey Kralstein, Grzegorz Wallner, Richard W. McCallum, Jerzy Sarosiek  Clinical Gastroenterology and Hepatology  Volume 5, Issue 4, Pages (April 2007) DOI: /j.cgh Copyright © 2007 AGA Institute Terms and Conditions

2 Figure 1 Patient flow for the study.
Clinical Gastroenterology and Hepatology 2007 5, DOI: ( /j.cgh ) Copyright © 2007 AGA Institute Terms and Conditions

3 Figure 2 Individual salivary bicarbonate outputs in response to therapy with tegaserod in basal conditions. *P < .001 vs placebo (Wilcoxon test). Clinical Gastroenterology and Hepatology 2007 5, DOI: ( /j.cgh ) Copyright © 2007 AGA Institute Terms and Conditions

4 Figure 3 (A) Contribution of salivary and esophageal submucosal mucous glands to esophageal pre-epithelial defense before tegaserod. (B) Contribution of salivary and esophageal submucosal glands to esophageal pre-epithelial defense after tegaserod. Clinical Gastroenterology and Hepatology 2007 5, DOI: ( /j.cgh ) Copyright © 2007 AGA Institute Terms and Conditions


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