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The Hyperpolarization-Activated Cation Current Ih: The Missing Link Connecting Cannabinoids to Cognition  Geoffrey A. Vargish, Chris J. McBain  Neuron 

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Presentation on theme: "The Hyperpolarization-Activated Cation Current Ih: The Missing Link Connecting Cannabinoids to Cognition  Geoffrey A. Vargish, Chris J. McBain  Neuron "— Presentation transcript:

1 The Hyperpolarization-Activated Cation Current Ih: The Missing Link Connecting Cannabinoids to Cognition  Geoffrey A. Vargish, Chris J. McBain  Neuron  Volume 89, Issue 5, Pages (March 2016) DOI: /j.neuron Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Connecting Cannabinoid Function to Cognition
(A) Schematic diagram of cannabinoid type 1 receptor expression (CB1R) and hyperpolarization-activated cyclic nucleotide-gated (HCN) channel expression in hippocampal deep or superficial pyramidal cells (DPC and SPCs). (B) Diagram highlighting the intracellular pathway that connects CB1R activation to increased HCN-mediated Ih. (C) CB1R-mediated modulation of Ih influences temporal summation (left) as well as induction of Schaffer collateral LTP (middle) in SPCs. The CB1R- Ih pathway is also linked to impairments in spatial memory induced by CB1R agonists, such as cannabis, as highlighted by the object location memory test (right). Acute treatment with a CB1R agonist, WIN55,212-2, reduces object discrimination index in a CB1R- and HCN1-dependent manner. Neuron  , DOI: ( /j.neuron ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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