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Optimization of desflurane administration in morbidly obese patients: a comparison with sevoflurane using an ‘inhalation bolus’ technique  L.E.C. De Baerdemaeker,

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Presentation on theme: "Optimization of desflurane administration in morbidly obese patients: a comparison with sevoflurane using an ‘inhalation bolus’ technique  L.E.C. De Baerdemaeker,"— Presentation transcript:

1 Optimization of desflurane administration in morbidly obese patients: a comparison with sevoflurane using an ‘inhalation bolus’ technique  L.E.C. De Baerdemaeker, M.M.R.F. Struys, S Jacobs, N.M.M. Den Blauwen, G.R.P.J. Bossuyt, P Pattyn, E.P. Mortier  British Journal of Anaesthesia  Volume 91, Issue 5, Pages (November 2003) DOI: /bja/aeg236 Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Schematic representation of how variables were defined in the detailed analysis of the BIS profiles during an inhalation bolus. British Journal of Anaesthesia  , DOI: ( /bja/aeg236) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Individual calculated remifentanil plasma (Cp) and effect-site (Ce) concentrations in the desflurane (a and b) and sevoflurane (e and f) groups. Individual inspiratory (FI) (c and g) and end-tidal (d and h) concentrations for desflurane and sevoflurane. British Journal of Anaesthesia  , DOI: ( /bja/aeg236) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

4 Fig 3 Individual BIS (a) and haemodynamic profiles for all patients in the sevoflurane group. Heart rate (HR) is shown in (b); systolic (SYS) and mean (MAP) arterial pressure are shown in (c) and (d), respectively. British Journal of Anaesthesia  , DOI: ( /bja/aeg236) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

5 Fig 4 Individual BIS (a) and haemodynamic profiles for all patients in the desflurane group. Heart rate (HR) is shown in (b); systolic (SYS) and mean (MAP) arterial pressure are shown in (c) and (d), respectively. British Journal of Anaesthesia  , DOI: ( /bja/aeg236) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

6 Fig 5 Time-synchronized (beginning at loss of consciousness) analysis of the differences in BIS between groups. The mean is plotted as a continuous line; the upper and lower 95% CI are plotted as dotted lines. British Journal of Anaesthesia  , DOI: ( /bja/aeg236) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

7 Fig 6 Changes in MAP (mean arterial pressure) for all patients after an inhalation bolus of volatile anaesthetics for S and D, sevoflurane and desflurane, respectively. The baseline measure was taken at the start of the inhalation bolus and marked as ‘Baseline’ and the highest or lowest measure within 8 min after the start of the inhalation bolus is marked as ‘Trend’. British Journal of Anaesthesia  , DOI: ( /bja/aeg236) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

8 Fig 7 Survival distribution function for different recovery measures. Sevoflurane group (sevoflurane) data plotted as dotted lines and desflurane group data as straight lines. British Journal of Anaesthesia  , DOI: ( /bja/aeg236) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions


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