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Monitoring plasma levels of ganciclovir in AIDS patients receiving oral ganciclovir as maintenance therapy for CMV retinitis  C. Piketty, C. Bardin, J.

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Presentation on theme: "Monitoring plasma levels of ganciclovir in AIDS patients receiving oral ganciclovir as maintenance therapy for CMV retinitis  C. Piketty, C. Bardin, J."— Presentation transcript:

1 Monitoring plasma levels of ganciclovir in AIDS patients receiving oral ganciclovir as maintenance therapy for CMV retinitis  C. Piketty, C. Bardin, J. Gilquin, A. Gairard, M.D. Kazatchkine, F. Chast  Clinical Microbiology and Infection  Volume 6, Issue 3, Pages (March 2000) DOI: /j x Copyright © 2000 European Society of Clinical Infectious Diseases Terms and Conditions

2 Figure 1 Distribution of trough ganciclovir plasma levels at steady state in 14 patients treated with oral ganciclovir 1000 mg three times daily. Clinical Microbiology and Infection 2000 6, DOI: ( /j x) Copyright © 2000 European Society of Clinical Infectious Diseases Terms and Conditions

3 Figure 2 Proportion of patients remaining free of progression on maintenance therapy with oral ganciclovir as determined by fundoscopy assessments (Kaplan-Meier estimates). (○) Patients exhibiting trough plasma levels of ganciclovir <0.6 mg/L (n = 9); (O) patients exhibiting trough plasma levels of ganciclovir ≥0.6 mg/L (n = 5); P = 0.58 using a log-rank comparison test. Clinical Microbiology and Infection 2000 6, DOI: ( /j x) Copyright © 2000 European Society of Clinical Infectious Diseases Terms and Conditions


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